Low-Fat, High-Fiber Diet Favorably Affects Several
Independent Risk Markers of Ischemic Heart Disease:
Observations on Blood Lipids, Coagulation, and Fibrinolysis
from a Trial of Middle-Aged Danes
Low-Fat, High-Fiber Diet Favorably Affects Several Independent Risk Markers of Ischemic Heart Disease: Observations on Blood Lipids, Coagulation, and Fibrinolysis from a Trial of Middle-Aged Danes
Marckmann P; Sandstrom B; Jespersen J.
American Journal of Clinical Nutrition, 1994 Apr, 59(4):935-9
Abstract:
We
served a low-fat (28% of energy), high-fiber (3.3 g/MJ) diet
according to Nordic nutrition recommendations (Rec diet), and a
high-fat diet (39% of energy) corresponding to the average Danish
diet (Dane diet) for periods of 2 weeks in a randomized crossover
study of 21 healthy middle-aged individuals.
The Rec diet resulted in lower serum concentrations of low-density-lipoprotein (LDL) cholesterol (medians: 2.77 vs 3.04 mmol/L, P < 0.001) and high-density-lipoprotein (HDL) cholesterol (1.08 vs 1.24 mmol/L, P < 0.001), and higher fasting triglycerides (1.11 vs 0.86 mmol/L, P = 0.04) than did the Dane diet. Furthermore, the Rec diet lowered plasma factor VII coagulant activity (FVIIc) (88% vs 96%, P = 0.002) and raised plasma fibrinolytic activity. Our observations indicate that a low-fat, high-fiber diet may not only reduce the atherogenic but also the thrombogenic tendency of an individual compared with a diet corresponding to the average Danish diet.
