The Role
of Glucosamine Sulfate and Chondroitin Sulfates in the Treatment of Degenerative Joint
Disease.
Altern Med Rev, 1998 Feb,
3(1):27-39.
Kelly GS.
Abstract: Successful treatment
of osteoarthritis must effectively control pain, and should slow down or reverse
progression of the disease. Biochemical and pharmacological data combined with animal and
human studies demonstrate glucosamine sulfate is capable of satisfying these criteria.
Glucosamine sulfate's primary biological role in halting or
reversing joint degeneration appears to be directly due to its ability to act as an
essential substrate for, and to stimulate the biosynthesis of, the glycosaminoglycans and
the hyaluronic acid backbone needed for the formation of proteoglycans found in the
structural matrix of joints. Chondroitin sulfates, whether they are absorbed intact or
broken into their constituent components, similarly provide additional substrates for the
formation of a healthy joint matrix.
Evidence also supports the oral
administration of chondroitin sulfates for joint disease, both as an agent to slowly
reduce symptoms and to reduce the need for non-steroidal anti-inflammatory drugs. The
combined use of glucosamine sulfate and chondroitin sulfates in the treatment of
degenerative joint disease has become an extremely popular supplementation protocol in
arthritic conditions of the joints. Although glucosamine sulfate and chondroitin sulfates
are often administered together, there is no information available to demonstrate the
combination produces better results than glucosamine sulfate alone.
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